Gilbert’s Syndrome: Understanding a Common Liver Condition:

A Brisbane Naturopath Approach

High Total Bilirubin across repeated blood tests is the biggest clue for Gilbert’s Syndrome – anyone with a consistent pattern of >15ummol/L, not just a one off elevation. It often goes undiagnosed unless routine blood tests reveal elevated bilirubin levels.

Gilbert’s Syndrome is a common, liver condition characterised by elevated levels of unconjugated bilirubin in the blood.

It is primarily caused by a genetic mutation in the UGT1A1 gene, which codes for the enzyme uridine diphosphate-glucuronosyltransferase (UGT).

Elevated levels of unconjugated bilirubin in the blood can have various effects on health, including:

1. Hormone Metabolism: Bilirubin is known to affect hormone metabolism, including female and male hormones. Elevated bilirubin levels may interfere with hormone regulation, potentially affecting menstrual cycles in females and testosterone levels in males.

2. Neurotransmitters and Mood: High bilirubin levels have been associated with alterations in neurotransmitter metabolism, particularly serotonin. Serotonin plays a crucial role in mood regulation, and disruptions in its metabolism may contribute to symptoms of depression and anxiety in individuals with Gilbert’s Syndrome.

3. Bowel Regularity: Changes in bowel habits, including constipation or diarrhea. Bilirubin has been shown to affect intestinal motility, and alterations in bilirubin levels may impact bowel regularity.
4. Nausea: Fatty and fried foods can exacerbate symptoms of nausea and queasiness in individuals with Gilbert’s Syndrome. Bilirubin levels may influence gastrointestinal function, and certain foods, particularly those high in fat, may exacerbate symptoms of nausea and gastrointestinal discomfort.
5. Intestinal Hyper-permeability: Elevated bilirubin levels have been linked to increased intestinal permeability, also known as “leaky gut.” Intestinal hyper-permeability can lead to the passage of toxins and bacteria from the gut into the bloodstream, potentially triggering immune responses and inflammation.

While there is no specific treatment for Gilbert’s Syndrome, certain nutrients and supplements may help support liver function and overall health in individuals with this condition.

Here are some nutrients and supplements that may be beneficial:

1. Antioxidants help protect liver cells from oxidative damage and inflammation. Foods rich in antioxidants include fruits, vegetables, nuts, seeds, and green tea. Supplements such as vitamin C, vitamin E, and alpha-lipoic acid.
2. B-vitamins play a crucial role in liver metabolism and detoxification processes. Vitamin B6, B12, and folate are particularly important for methylation pathways, which may be impaired in individuals with Gilbert’s Syndrome. Foods rich in B-vitamins include leafy greens, whole grains, legumes, nuts, seeds, and animal products. B-complex supplements may also be beneficial.
3. Herbal medicines – bile-stimulating & bitter herbal medicines help increase bile flow, reduce gallbladder stagnation and increase overall bilirubin output.

Milk thistle (Silybum marianum) is an herbal remedy commonly used to support liver health and protect against liver damage.

4. Calcium D-Glucarate: Calcium D-glucarate is a calcium salt of D-glucaric acid, a natural substance found in fruits and vegetables. It is often used as a supplement to support glucuronidation and helps to inhibiting the enzyme beta-glucuronidase to support hormone balance in the body.
5. Omega-3 fatty acids, found in fatty fish (such as salmon, mackerel, and sardines), flaxseeds, chia seeds, and walnuts, have anti-inflammatory effects and may help support liver function. Fish oil supplements or algae-based omega-3 supplements are alternative sources.
6. Probiotics: Probiotics are beneficial bacteria that help maintain a healthy balance of gut microbiota and support gastrointestinal health. Some research suggests that probiotic supplementation may help reduce bilirubin levels and improve symptoms in individuals with Gilbert’s Syndrome.
7. Vitamin D deficiency has been associated with liver dysfunction and may exacerbate symptoms in individuals with Gilbert’s Syndrome. Ensuring adequate vitamin D intake through sunlight exposure, dietary sources (such as fatty fish, fortified foods, and supplements), or supplementation may be beneficial.
8. Choline is a nutrient important for liver function and lipid metabolism. Foods rich in choline include eggs, meat, fish, dairy products, nuts, and cruciferous vegetables. Choline supplements may also be beneficial, especially for individuals with impaired liver function.

Here are some of the benefits Of Gilbert’s Syndrome!

1. Reduced Risk of Atherosclerosis: Some research suggests that individuals with Gilbert’s Syndrome may have a reduced risk of developing atherosclerosis, a condition characterized by the buildup of plaque in the arteries. Elevated bilirubin levels in Gilbert’s Syndrome have been associated with improved endothelial function and reduced oxidative stress, which may contribute to cardiovascular protection.

2. Antioxidant Properties: Bilirubin, the pigment responsible for the characteristic jaundice seen in Gilbert’s Syndrome, exhibits antioxidant properties. Elevated bilirubin levels may help protect cells and tissues from oxidative damage caused by free radicals, potentially reducing the risk of oxidative stress-related diseases.

3. Lower Risk of Cancer: Some studies have suggested that individuals with Gilbert’s Syndrome may have a lower risk of certain types of cancer, including gastrointestinal and lung cancers. The antioxidant and anti-inflammatory effects of bilirubin may play a role in this protective effect against cancer development.

4. Neuroprotection: Bilirubin has been shown to exert neuroprotective effects in the brain, potentially reducing the risk of neurodegenerative diseases such as Parkinson’s and Alzheimer’s disease. Bilirubin’s antioxidant and anti-inflammatory properties may help protect neurons from damage and support brain health.

5. Improved Immune Function: Bilirubin has been found to modulate immune responses and inflammation, potentially enhancing immune function. Individuals with Gilbert’s Syndrome may have a more balanced immune response, which could contribute to overall health and well-being.

Alcohol consumption can potentially affect individuals with Gilbert’s Syndrome in several ways, primarily due to the liver’s role in processing alcohol and bilirubin.

While Gilbert’s Syndrome is generally considered a benign condition, alcohol intake may exacerbate certain symptoms or complications associated with the condition.

Overall, while moderate alcohol consumption may not pose significant risks for individuals with Gilbert’s Syndrome, excessive or chronic alcohol intake should be avoided. It’s essential for individuals with Gilbert’s Syndrome to maintain a healthy lifestyle, including limiting alcohol consumption, eating a balanced diet, exercising regularly, and avoiding smoking or illicit drug use. Consulting with a healthcare provider can provide personalized guidance on alcohol consumption and overall health management for individuals with Gilbert’s Syndrome.

Disclaimer: This page is informational purposes only and does not constitute medical advice. The information provided on this page is not intended to diagnose, treat, cure, or prevent any disease or health condition. It is important to consult with a qualified healthcare professional for any health concerns or before making any decisions related to your health or wellbeing.

Morkare Natural Clinic is not responsible for any misinformation or inaccuracies that may be found on this page. Always seek the advice of a qualified medical professional for any diagnosis or treatment.

Morkare Natural Clinic offers complementary solutions that may be beneficial when used in conjunction with conventional medical treatment. However, it is important to note that Morkare Natural Clinic is not a substitute for conventional medical care.